Complex Regional Pain Syndrom (CRPS) is a painful and debilitating disorder primarily affecting one or more extremities. The key features in CRPS are spontaneous pain, allodynia, hyperalgesia, edema, temperature change, abnormal discoloration and sweat activity, trophic changes, and muscle dysfunction. It usually follows some initial antecedent event such as trauma or surgery. Although CRPS most frequently affects the limbs, it can occur anywhere in the body. A CRPS-like syndrome may be observed in patients with certain neoplasms (e.g., lung, breast, central nervous system, and ovarian cancers) and in patients after myocardial infarction or strokes.
